Dieses Open-Access-Buch gibt aktuelle interdisziplinäre Forschungseinblicke rund um das Fab City-Konzept. Ein Ansatz, der beschreibt, wie Produktions- und Konsumptionsweisen gestaltet werden können, sodass einerseits globale Kollaboration in und durch Communities von der Ideengenerierung bis zur Produktentwicklung physischer Güter mittels quelloffener Technologien (Open Source Software und Hardware) ermöglicht wird und andererseits die Produktion dieser Güter lokal und somit möglichst nahe am Ort des Bedarfs sowie dezentral im Sinne einer verteilten Produktion erfolgen kann, beispielsweise in Fab(rication) Labs. Ziel ist die Schaffung einer (...) möglichst nachhaltigen Produktion bzw. Wertschöpfung. Ökologisch nachhaltig, indem lange Transportwege vermieden und auf Grundlage von Kreislaufprinzipien lokale Stoffkreisläufe geschlossen werden. Ökonomisch nachhaltig, indem durch quelloffene Technologien Wettbewerbsbeschränkungen und durch föderierte Ansätze Abhängigkeiten vermieden werden. Sozial nachhaltig durch ein partizipatives Wertschöpfungssystem, in dem der Zugang zu Wissen und Knowhow sowie zu Produktionsmitteln unbeschränkt ist. Über den gesamten Produktentstehungsprozess und -lebenszyklus enthält das vorliegende, bilinguale Werk in deutscher und englischer Sprache Beiträge aus den Bereichen Citizen & Collaborative Innovation and Design, Circular Design & Economy, Open-Source-Software-Tools für die Entwicklung von Open Source Hardware, Digital Product Passport, föderierte (Open-Source-) Systeme, die Verbreitung von Open Source Hardware sowie technical literacy und economic governance. Prof. Neil Gershenfeld, Director of MIT's Center for Bits and Atoms, and Chairman of the board of The Fab Foundation: "For many years the growth of cities has been an inexorable trend, with cities acting as regional magnets and engines; the resources enabling a Fab City can also help expand opportunity beyond cities. There is now an opportunity and need for labs that can develop, deploy, and measure the frontiers of Fab City technologies. This book provides a much-needed snapshot of the current state of that challenge." Tomas Diez, Executive Director of the Fab City Foundation: "This book is an invitation for large-scale collaboration to build distributed system that can support the development of alternative modes of production, in line with the social and ecological needs of our time.". (shrink)

In this paper, I argue that established responses to the demandingness objection fail to acknowledge an alternative explanation of the intuitive pull of this objection for a significant subset of norms being subject to it. This is the class of imperfect collective duties, which give rise to conceptually distinct objections from fairness that nonetheless permeate many clear examples of intuitively problematic moral demands. Such duties obtain where it is morally required to attain a certain outcome O, yet obtaining O does (...) not require each moral agent to do as much as they individually can but instead requires a finite amount of effort that can be variously allocated to different agents – think of classic collective action problems such as protesting against an unjust policy, lobbying a government, donating to disaster relief, or hosting refugees. -/- In such cases, our collective ability to attain O grounds a collective duty C to attain O, but this collective duty can be translated into various schemes of individual duties P to contribute towards O. Accordingly, this decomposition of C raises a problem of distributive justice. In fact, many intuitive objections to unfair distributions in such cases can be readily accounted for with the conceptual apparatus of prominent theories of distributive justice, but not by standard theories of interpersonal morality. For instance, the moral relevance of the fact that performing a composite duty P is more burdensome for agent A than for agent B can readily be explained in luck-egalitarian terms. Yet both utilitarians and contractualists could not account for this fact independently of an appeal to the demandingness objection, provided that the moral importance of the outcome attainable through P still trumps reasons against it that are due to the burden borne by the agent. -/- Put briefly, then, we need to clearly distinguish objections that morality demands _too much_ of me from objections that morality demands too much _of me_. Doing so is likely to make accepting the demandingness of morality properly construed more intuitively plausible, perhaps as mitigated by certain existing responses. (shrink)

According to the knowledge norm of belief, one should believe p only if one knows p. However, it can easily seem that the ordinary notion of belief is much weaker than the knowledge norm would have it. It is possible to rationally believe things one knows to be unknown The aim of belief, Oxford University Press, Oxford, 2013). One response to this observation is to develop a technical notion of ‘outright’ belief. A challenge for this line of response is to (...) find a way of getting a grip on the targeted notion of belief. In order to meet this challenge, I characterize ‘outright’ belief in this paper as the strongest belief state implied by knowledge. I show that outright belief so construed allows this notion to play important theoretical roles in connection with knowledge, assertion and action. (shrink)

Individuals regaining reliable day-to-day walking function after incomplete spinal cord injury report persisting unsteadiness when confronted with walking challenges. However, quantifiable measures of walking capacity lack the sensitivity to reveal underlying impairments of supra-spinal locomotor control. This study investigates the relationship between intramuscular coherence and corticospinal dynamic balance control during a visually guided Target walking treadmill task. In thirteen individuals with iSCI and 24 controls, intramuscular coherence and cumulant densities were estimated from pairs of Tibialis anterior surface EMG recordings during (...) normal treadmill walking and a Target walking task. The approximate center of mass was calculated from pelvis markers. Spearman rank correlations were performed to evaluate the relationship between intramuscular coherence, clinical parameters, and center of mass parameters. In controls, we found that the Target walking task results in increased high-frequency intramuscular coherence, which negatively related to changes in the center of mass movement, whereas this modulation was largely reduced in individuals with iSCI. The impaired modulation of high-frequency intramuscular coherence during the Target walking task correlated with neurophysiological and functional readouts, such as motor-evoked potential amplitude and outdoor mobility score, as well as center of mass trajectory length. The Target walking effect, the difference between Target and Normal walking intramuscular coherence, was significantly higher in controls than in individuals with iSCI [F = 13.042, p < 0.001]. Intramuscular coherence obtained during challenging walking in individuals with iSCI may provide information on corticospinal gait control. The relationships between biomechanics, clinical scores, and neurophysiology suggest that intramuscular coherence assessed during challenging tasks may be meaningful for understanding impaired supra-spinal control in individuals with iSCI. (shrink)

Background: Although convolutional neural networks (CNNs) achieve high diagnostic accuracy for detecting Alzheimer’s disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine. One important reason for this is a lack of model comprehensibility. Recently developed visualization methods for deriving CNN relevance maps may help to fill this gap as they allow the visualization of key input image features that drive the decision of the model. We investigated whether models with higher accuracy (...) also rely more on discriminative brain regions predefined by prior knowledge. Methods: We trained a CNN for the detection of AD in N = 663 T1-weighted MRI scans of patients with dementia and amnestic mild cognitive impairment (MCI) and verified the accuracy of the models via cross-validation and in three independent samples including in total N = 1655 cases. We evaluated the association of relevance scores and hippocampus volume to validate the clinical utility of this approach. To improve model comprehensibility, we implemented an interactive visualization of 3D CNN relevance maps, thereby allowing intuitive model inspection. Results: Across the three independent datasets, group separation showed high accuracy for AD dementia versus controls (AUC ≥ 0.91) and moderate accuracy for amnestic MCI versus controls (AUC ≈ 0.74). Relevance maps indicated that hippocampal atrophy was considered the most informative factor for AD detection, with additional contributions from atrophy in other cortical and subcortical regions. Relevance scores within the hippocampus were highly correlated with hippocampal volumes (Pearson’s r ≈ −0.86, p < 0.001). Conclusion: The relevance maps highlighted atrophy in regions that we had hypothesized a priori. This strengthens the comprehensibility of the CNN models, which were trained in a purely data-driven manner based on the scans and diagnosis labels. The high hippocampus relevance scores as well as the high performance achieved in independent samples support the validity of the CNN models in the detection of AD-related MRI abnormalities. The presented data-driven and hypothesis-free CNN modeling approach might provide a useful tool to automatically derive discriminative features for complex diagnostic tasks where clear clinical criteria are still missing, for instance for the differential diagnosis between various types of dementia. (shrink)

Background Executive functions (EFs) not only play an important role in shaping adolescent’s goal-directed, future-oriented cognitive skills under relatively abstract, non-affective conditions (Cool EF), but also under motivationally significant, affective conditions (Hot EF). Empirical evidence suggest a link between EF, exercise and physical activity, specifically elite adult athletes appear to outperform amateur athletes in Cool EF; however, no previous studies have examined the relationship between Hot and Cool EFs and impulsivity during the developmentally sensitive period of adolescence comparing different types (...) of sport (open- vs. closed-skills), and levels (elite athletes vs. amateurs). Methods A total 86 boys and girls between 13 and 15 years of age (mean: 14.0, SD : 0.79) from different sports (track-and-field; team handball) were recruited. Participants were further divided into two groups: (a) 40 elite, and (b) 46 amateur athletes. They completed four Cool EF tasks including Trail-Making Test, Trail-Walking-Test, Flanker task, n-back-task, and one Hot EF task on Game of Dice task. Data on subjective impulsivity (UPPS Impulsive Behavior Scale; Barratt Impulsiveness Scale-15) was also collected. Results There was a significant overall effect for expertise in favor of elite athletes (Wilks’ Lambda = 0.61, F (14,69) = 3.19, p = 0.001, η p 2 = 0.393), but no overall main effect for type of sport or an interaction for expertise by type of sport. Specifically, elite athletes showed significantly better performances on dual tasks. For Hot EF, there were no main effects for type of sport, expertise level, training experience or training duration. We also found positive correlations among Cool EF and impulsivity measures, and between Hot EF and Impulsivity, but no significant relationship between Cool and Hot EF. Conclusion The current understanding of the decisive cognitive abilities does not correspond to sporting reality, so that the tests frequently used are not sensitive enough to distinguish between elite and amateur athletes or different sports. However, it should also be remembered that the factors underlying complex sporting performance are multidimensional and are obviously difficult to trace back to selected partial aspects. Without being able to answer this question conclusively, we proposed a 4-D classification of experimental paradigms, in which we differentiate between tasks of different specificity, between Cool and Hot EF, and between task complexity, and type of sport. (shrink)

Este artigo recorda os principais aspectos e motivações da Expedição Langsdorff, missão de reconhecimento do interior do Brasil iniciada em 1821, composta pelo cônsul russo barão Langsdorff, o pintor alemão Moritz Rugendas, Aimé-Adrien Taunay, Nicolas-Antoine Taunay, o polígrafo Hercules Florence e o especialista em mapas Néster G. Rubtsov. Busca diferenças entre esta expedição e iniciativas outras, a título de exemplo, as dos bandeirantes e jesuítas, bem como a expedição indigenista de Rondon, e propõe o aprofundamento das investiga­ções. Apresenta atributos (...) resgatados pela poesia brasileira contemporânea e elementos cons­titutivos da identidade cultural brasileira presentes na Expedição Langsdorff, os quais os auto­res sugerem ser relevantes para pesquisadores do tema e para a inserção do Brasil no contexto internacional político, diplomático e econômico nos tempos hodiernos. (shrink)

Background: Despite a gradual shift in the focus of medical care among terminally ill patients to a palliative model, studies suggest that many children with life-limiting chronic illnesses continue to die in hospital after prolonged periods of inpatient admission and mechanical ventilation.Objectives: To examine the characteristics and location of death among hospitalised children, investigate yearwise trends in these characteristics and test the hypothesis that professional ethical guidance from the UK Royal College of Paediatrics and Child Health would lead to significant (...) changes in the characteristics of death among hospitalised children.Methods: Routine administrative data from one large tertiary-level UK children’s hospital was examined over a 7-year period for children aged 0–18 years. Demographic details, location of deaths, source of admission , length of stay and final diagnoses were studied. Statistical significance was tested by the Kruskal–Wallis analysis of ranks and median test , χ2 test and Cochran–Armitage test .Results: Of the 1127 deaths occurring in hospital over the 7-year period, the majority were among infants. The main diagnoses at death included congenital malformations , perinatal diseases , cardiovascular disorders and neoplasms . Most deaths occurred in an intensive care unit environment , with a significant increase over the years . There was a clear increase in the proportion of admissions from in-hospital among the ICU cohort . Infants with congenital malformations and perinatal conditions were more likely to die in an ICU , and older children with malignancy outside the ICU . Children stayed for a median of 13 days on a hospital ward before being admitted to an ICU where they died.Conclusions: A greater proportion of hospitalised children are dying in an ICU environment. Our experience indicates that professional ethical guidance by itself may be inadequate in reversing the trends observed in this study. (shrink)

table ronde du Centre national de la recherche scientifique, Paris, 27-29 mars 1979. Huygens et la France (Paris, Vrin, 1981, p. 99-114) CHRISTIAAN HUYGENS VU PAR LEIBNIZ par Albert HEINEKAMP (*) (Leibniz-Archiv, Hannover) Les ...

Aim: Patients with advanced cancer need information about end-of-life treatment options in order to make informed decisions. Clinicians vary in the frequency with which they initiate these discussions.Patients and methods: As part of a long-term longitudinal study, patients with an expected 2-year survival of less than 50% who had advanced gastrointestinal or lung cancer or amyotrophic lateral sclerosis were interviewed. Each patient’s medical record was reviewed at enrollment and at 3 months for evidence of the discussion of patient wishes concerning (...) ventilator support, artificial nutrition and hydration , resuscitation and hospice care. A Kaplan–Meier analysis was also performed and 2-year survival calculated.Results: 60 cancer and 32 ALS patients were enrolled. ALS patients were more likely than cancer patients to have evidence of discussion about their wishes for ventilator support , ANH , DNR and hospice care . At 6 months, 91% of ALS patients were alive compared with 62% of cancer patients; at 2 years, 63% of ALS patients were alive compared with 23% of cancer patients .Conclusions: Cancer patients were less likely than ALS patients to have had documented advanced care planning discussions despite worse survival. This may reflect perceptions that ALS has a more predictable course, that advanced cancer has a greater number of treatment options, or differing views about hope. Nevertheless, cancer patients may be less adequately prepared for end-of-life decision-making. (shrink)

Hintikka, J. Knowing how, knowing that, and knowing what: observations on their relation in Plato and other Greek philosophers.--Hedenius, I. The concept of punishment.--Marc-Wogau, K. On the concept of dialectial development in Marxism.--Ekelöf, P. O. Definitions and concept formation in the law.--Hermerén, G. The existence of aesthetic qualities.--Regnéll, H. Explanation in analytical philosophy.--Furberg, M. On questions and pseudo-problems.--Moritz, M. Imperative implication and conditional imperatives.--Sosa, E. Standard conditions.--Danielsson, S. On the strength of commitments.--Aqvist, L. The emotive theory of ethics in (...) the light of recent developments in formal semantics and pragmatics.--Von Wright, G. H. Truth as modality. A contribution to the logic of sense and nonsense.--Hansson, B. and Gärdenfors, P. A guide to intentional semantics.--Kanger, S. Entailment.--Edman, M. Adding independent pieces of evidence.--Lindström, P. A characterization of elementary logic.--Woodruff, P. W. On constructive nonsense logic.--Segerberg, K. Halldén's theorem on Post completeness.--Philosophical works by Sören Halldén. (shrink)

В книге отражена деятельность ведущих ученых, специалистов, руководителей, внесших большой вклад в развитие Философского факультета МГУ имени М. В. Ломоносова.

Studies in Stoicism contains six unpublished and seven republished essays, the latter incorporating additions and changes which Brunt wished to be made. The papers have been integrated and arranged in chronological order by subject matter, with an accessible lecture to the Oxford Philological Society serving as Brunt's own introduction.

This paper discusses the utilization of pilots' physiological indications such as electroencephalographic signals, ocular parameters, and pilot performance-based quantitative metrics to estimate cognitive workload. The study aims to derive a non-invasive technique to estimate pilot's cognitive workload and study their correlation with standard physiological parameters. Initially, we conducted a set of user trials using well-established psychometric tests for evaluating the effectiveness of pupil and gaze-based ocular metrics for estimating cognitive workload at different levels of task difficulty and lighting conditions. Later, (...) we conducted user trials with the NALSim flight simulator using a business class Learjet aircraft model. We analyzed participants' ocular parameters, power levels of different EEG frequency bands, and flight parameters for estimating variations in cognitive workload. Results indicate that introduction of secondary task increases pilot's cognitive workload significantly. The beta frequency band of EEG, nearest neighborhood index specifying distribution of gaze fixation, L1 Norm of power spectral density of pupil diameter, and the duty cycle metric indicated variations in cognitive workload. (shrink)